MHC Molecules: Structure and Genetics
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چکیده
BIG PICTURE: T cells are a critical player in the adaptative immune system, but unlike B cells whose B Cell Receptor (BCR) can interact with soluble antigen, the T cell can only see antigen in the form of short peptides that has been processed and displayed on the cell surface bound to MHC Class I and Class II molecules. Each TCR is clonotypic meaning that it has undergone the process of positive and negative selection in the thymus, and the TCR is now programmed to recognize: [1] a specific non-self peptide in the [2] context (or orientation) of a [3] specific MHC molecule (MHC restricted). Clearly, the MHC:peptide complex is as critical to adaptative immunity as is the TCR. And likewise, it is important to understand the genes, structure, and cell biology of the MHC to understand its function, and how polymorphisms in MHC molecules impact the overall creation and diversity of the immune system.
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